Nabumetone is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), and is primarily used to treat pain, inflammation and stiffness caused by arthritis.

Relafen works by reducing the level of hormones in the body that can cause pain and inflammation. In addition to the warnings provided with the packaging of the medication and those related by a physician, there are other important concerns that users of Relafen should know about.

A severe adverse reaction called Stevens-Johnson Syndrome has been linked to use of the drug Relafen.

The symptoms of Stevens-Johnson Syndrome can begin as some form of upper respiratory infection, including also fever, sore throat, inflammation of the mouth, chills, headaches, aching of the joints, and generally feeling ill. After onset, Stevens-Johnson Syndrome will continue to develop, affecting the various mucous membranes of the body, including the mouth, esophagus, nostrils, eyes, genitals, and anal regions. Lesions may develop and the skin may blister or even detach in severe cases.

SUBJECT: Analysis and recommendations for Agency action regarding non-steroidal anti-inflammatory drugs and cardiovascular risk

Following a thorough review of the available data we have reached the following conclusions regarding currently approved COX-2 selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs)1 and the risk of adverse cardiovascular (CV) events:2

• The three approved COX-2 selective NSAIDs (i.e., celecoxib, rofecoxib, and valdecoxib) are associated with an increased risk of serious adverse CV events compared to placebo. The available data do not permit a rank ordering of these drugs with regard to CV risk.

• Data from large long-term controlled clinical trials that have included a comparison of COX-2 selective and non-selective NSAIDs do not clearly demonstrate that the COX-2 selective agents confer a greater risk of serious adverse CV events than non-selective NSAIDs.

FDA label Reflafen, Oct 2000 Relafen (nabumetone) is a naphthylalkanone designated chemically as 4-(6-methoxy-2-naphthalenyl)-2-butanone.

Stevens Johnson Syndrome

Complete and submit the following information. Fields with (*) are required.

If you prefer, you may contact us at: (817) 334-0762 or toll free at (800) 803-3784.

This information will be kept private and confidential and used for the sole purpose of evaluating your case.

Please note that without a phone number or e-mail address, we will not be able to contact you.

You will be contacted by an attorney or paralegal, who is experienced in the area of drug injury law.

Submitting this form does not create an attorney-client relationship: Agree Disagree
*Full Name of person needing assistance.	*E-Mail
*Home phone	Work phone
Cell phone	Address
City, State, Zip	Name of Medicine, Drug, or Over the Counter medicine
What is best way to reach you? (e-mail, phone, letter)	*Injured in City, State
*Describe
*List all medication
*Please enter the digits displayed here:
For Parents or Guardians If the person in need of assistance is a minor or is a disabled adult with an appointed guardian we will need to communicate with that parent or guardian.

Relafen / Nabumetone

Stevens Johnson Syndrome