Ibuprofen is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). It is an over the counter drug primarily used to reduce the fever, pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, and abdominal cramps associated with menstruation. Children's Motrin is an over the counter drug primarily used to reduce fever in children.

SUBJECT: Analysis and recommendations for Agency action regarding non-steroidal anti-inflammatory drugs and cardiovascular risk

Following a thorough review of the available data we have reached the following conclusions regarding currently approved COX-2 selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs)1 and the risk of adverse cardiovascular (CV) events:2

• The three approved COX-2 selective NSAIDs (i.e., celecoxib, rofecoxib, and valdecoxib) are associated with an increased risk of serious adverse CV events compared to placebo. The available data do not permit a rank ordering of these drugs with regard to CV risk.

• Data from large long-term controlled clinical trials that have included a comparison of COX-2 selective and non-selective NSAIDs do not clearly demonstrate that the COX-2 selective agents confer a greater risk of serious adverse CV events than non-selective NSAIDs.

Stevens Johnson Syndrome

Complete and submit the following information. Fields with (*) are required.

If you prefer, you may contact us at: (817) 334-0762 or toll free at (800) 803-3784.

This information will be kept private and confidential and used for the sole purpose of evaluating your case.

Please note that without a phone number or e-mail address, we will not be able to contact you.

You will be contacted by an attorney or paralegal, who is experienced in the area of drug injury law.

Submitting this form does not create an attorney-client relationship: Agree Disagree
*Full Name of person needing assistance.	*E-Mail
*Home phone	Work phone
Cell phone	Address
City, State, Zip	Name of Medicine, Drug, or Over the Counter medicine
What is best way to reach you? (e-mail, phone, letter)	*Injured in City, State
*Describe
*List all medication
*Please enter the digits displayed here:
For Parents or Guardians If the person in need of assistance is a minor or is a disabled adult with an appointed guardian we will need to communicate with that parent or guardian.

Motrin / Ibuprofen

Stevens Johnson Syndrome