Medical Literature |
Risks
of Stevens Johnson Syndrome (SJS / TEN) |
| Dermatology Online Journal |
"Severe skin adverse drug reactions can result in death. Toxic epidermal necrolysis (TEN) has the highest mortality (30-35%); Stevens-Johnson syndrome and transitional forms correspond to the same syndrome, but with less extensive skin detachment and a lower mortality (5-15%)..." etc.
http://dermatology.cdlib.org/DOJvol8num1/reviews/drugrxn/ghislain.html |
| Wilmer Eye Institute at Johns Hopkins > Conditions |
"Stevens-Johnson Syndrome (SJS) is a disorder that causes painful blisters and lesions on the skin and mucous membranes and can cause severe eye problems. The most common cause of SJS is an adverse allergic drug reaction......"
http://www.hopkinsmedicine.org/wilmer/Conditions/stevens-johnson.html |
| Stevens-Johnson syndrome and toxic epidermal necrolysis are often drug induced |
"Toxic epidermal necrolysis (TEN) is an acute dermatologic disease, the presentation of which may constitute a true emergency. The disorder is characterized by widespread erythematous macules and targetoid lesions; full-thickness epidermal necrosis, at least focally; and involvement of more than 30% of the cutaneous surface. Commonly, the mucous membranes are also involved. Nearly all cases of toxic epidermal necrolysis are induced by medications, and the mortality rate can approach 40%"......
http://emedicine.medscape.com/article/1124127-overview |
| Skin Diseases |
Fritsch P; European Dermatology Forum: skin diseases in Europe. Skin diseases with a high public health impact: toxic epidermal necrolysis and Stevens-Johnson syndrome. Eur J Dermatol. 2008 Mar-Apr;18(2):216-7. |
| The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with nonsteroidal antiinflammatory drugs: a multinational perspective |
"The risk of the severe cutaneous adverse reactions Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) associated with use of nonsteroidal antiinflammatory drugs (NSAID). ".....
http://www.jrheum.org/content/30/10/2234.abstract |
| Stevens Johnson Syndrome: A Case Report |
"Stevens-Johnsonsyndrome(SJS)isalife-threateningvesicu-
lobullous diseasecharacterizedbyanacuteeruptionthat
involves theskinandmucousmembranes.Variousetiologic
factorshavebeenimplicatedasacauseofSJS,including
infection,vaccination,drugs,systemicdiseases,physical
agents, andfood.Drugsarethemostcommonlyblamed.".......
|
| An update on Stevens-Johnson syndrome and toxic epidermal necrolysis in children |
"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) and provides an update on the treatment of these conditions in children.".......
Newer agents such as cyclosporin, infliximab and plasmapheresis have shown promise in the treatment of SJS and TEN. |
| Drugs associated with Stevens-Johnson Syndrome in Children |
http://www.nelm.nhs.uk/en/NeLM-Area/News/2009---February/09/Drugs-associated-with-Stevens-Johnson-syndrome-in-children/
|
Lars
E French, 2006 Allergology International
|
"Toxic
Epidermal Necrolysis and
Stevens Johnson Syndrome: Our
Current Understanding"; Allergology International Vol
55, No1, 2006 http: www.jsaweb.jp
|
| Mockenhaupt
M., et al., Jour of Rheumatology, 2003 |
"The
Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Associated with Nonsteroidal Antiinflammatory Drugs: A Multinational
Perspective," Vol. 30, No. 10, pp. 2234-40 |
| Roujeau
J.C., et al., New England Jour of Med, 1995 |
"Medication Use and the Risk of Stevens-Johnson Syndrome or Toxic
Epidermal Necrolysis," Vol. 333, No. 24, pp. 1600-7
|
| Tadamasa
Yoshitake, 2007 |
"Erythema
multiforme and Stevens-Johnson syndrome following radiotherapy" Radiat
Med (2007) 25:27–30 DOI 10.1007/s11604-006-0093-3
|
| Fever
and rash in a child: when to worry? |
The differential diagnosis of a fever and rash
presenting in a pediatric patient is quite extensive. This
article is not all-inclusive but is meant to aid in the diagnosis
to differentiate serious, life-threatening eruptions from more
benign common rashes. |
|
Causes
of Stevens Johnson Syndrome (SJS / TEN) |
Mockenhaupt
M., et al., Jour of Rheumatology, 2003
|
"The
Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Associated with Nonsteroidal Antiinflammatory Drugs: A Multinational
Perspective," Vol. 30, No. 10, pp. 2234-40 |
| Ariane
Auquier-Dunant, Arch Dermatol.
2002;13;1019-1024 |
"Correlations
Between Clinical Patterns and Causes of Erythema Multiforme
Majus, Stevens-Johnson Syndrome, and Toxic Epidrmal Necrolysis", Arch
Dermatol Vol 138, Aug 2002 |
| CRAIG
K. SVENSSON, 2000 Pharmacol Rev 53:357–379 |
Cutaneous Drug Reactions
PHARMACOLOGICAL REVIEWS Vol. 53, No. 3
Copyright © 2000 by The American Society
for Pharmacology and Experimental Therapeutics 131/927786
|
| Roujeau
J.C., et al., New England Jour of Med, 1995 |
"Medication Use and the Risk of Stevens-Johnson Syndrome or Toxic
Epidermal Necrolysis," Vol. 333, No. 24, pp. 1600-7 |
Brkljaci
2006
|
Brkljaci N, Gracin S, Prkacin I, Sabljar-Matovinovi? M, Mrzljak
A, Nemet Z. Stevens-Johnson syndrome as an unusual adverse
effect of azithromycin. Acta Dermatovenerol Croat. 2006;14(1):40-5.
[view PubMed record (16603101)]
|
Stevens Johnson
Syndrome (SJS / TEN) Treatment and Outcomes |
| American College of Emergency Physicians, 2006 |
IVIG
Benefits Some Children With Stevens-Johnson Syndrome
|
| Stevens
Johnson Syndrome Foundation |
Treatments
from Stevens Johnson Syndrome Foundation about eyes /
eye sight / lens |
| Haber,
2004 |
Late
Outcomes in Adult Survivors of Toxic Epidermal Necrolysis
After Treatment in a Burn Center |
Ducic,
2002
Plastic
and Reconstructive Surgery |
"Outcome
of Patients with Toxic Epidermal Necrolysis Syndrome Revisited",
Vol. 110, No. 3, pp. 768 - 73 |
Pierre-Dominique
Ghislain M.D., 2002
Dermatol Online J 8(1), 2002
|
"Treatment
of Severe Drug Reactions" -- Stevens-Johnson Syndrome
and Toxic Epidermal Necrolysis;
Department of Dermatology,
Hospital Henri Mondor, University Paris
XII, Creteil, France
|
| Stern,
Arch Dermatol, 2000 |
"Improving
the Outcome of Patients
With Toxic Epidermal Necrolysis
and Stevens-Johnson Syndrome" |
| Garcia-Doval,
I, et. al., Arch Dermatol, 2000 |
"Toxic
Epidermal Necrolysis and Stevens Johnson Syndrome - Does
early withdrawal of Causative Drugs Decrease the Risk of
Death"; Arch Dermatol 2000, 136:323-327 |
| Facts
on Prevention, Detection & Treatment from John Hopkins
Medicine |
Cutaneous eruptions are the most frequently
reported adverse reactions to drugs, and most medications have
a 1% to 3% risk of producing immunologic manifestations. Drug-induced
allergic reactions occur in approximately 5% of the population,
and these reactions are responsible for approximately 6% to
10% of all adverse drug reactions. Of all medication classes,
b-lactam antibiotics, sulfonamides, and nonsteroidal anti-inflammatory
drugs (NSAIDs) are responsible for 80% of all reports of allergic
and pseudoallergic reactions. |
| |
|
|
However, carbamazepine, lamotrigine
and phenytoin were associated with
higher rates of rash. Oxcarbazepine and
phenobarbital had similar rates, but the
number of patients receiving these agents
was less, slightly eroding the confidence in
these numbers.
http://www.columbiaepilepsy.org/docs/patients/PN0905EpilepsyEssentials.pdf |
| Chang
YS, 2007 |
Chang YS, Huang FC, Tseng SH, Hsu CK, Ho CL,
Sheu HM. Erythema multiforme, Stevens-Johnson syndrome, and
toxic epidermal necrolysis: acute ocular manifestations, causes,
and management. Cornea. 2007 Feb;26(2):123-9. [view PubMed
record (17251797)] |
| Ang
LP 2007 |
Ang LP, Sotozono C, Koizumi N, Suzuki T, Inatomi
T, Kinoshita S. A comparison between cultivated and conventional
limbal stem cell transplantation for Stevens-Johnson syndrome.
Am J Ophthalmol. 2007 Jan;143(1):178-80. [view PubMed record
(17188066) |
| Clayton
NA 2007 |
"Management
of Dysphagia in Toxic Epidermal Necrolysis (TEN) and Stevens-Johnson
Syndrome (SJS)." |
| Burns.
2007 Apr 30; [Epub ahead of print] |
Toxic epidermal necrolysis (TEN) and Stevens-Johnson
syndrome (SJS): Experience with high-dose intravenous immunoglobulins
and topical conservative approach A retrospective analysis. |
| Dermatol
Clin. 2007 Apr;25(2):245-53. |
Recognition and management of severe cutaneous
drug reactions. |
What is Stevens-Johnson
Syndrome and Toxic Epidermal Necrolysis? |
| Laguna
C 2006 |
Laguna C, Martín B, Torrijos A, García-Melgares
ML, Febrer I. [Stevens-Johnson syndrome and toxic epidermal
necrolysis] Actas Dermosifiliogr. 2006 Apr;97(3):177-85. [view
PubMed record (16796964)] |
| |
Stevens-Johnson
Syndrome articles |
