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Study: 500,000 children sickened by prescriptions annually
September 28th, 2009 @ 4:13pm
By Marc Giauque

SALT LAKE CITY -- The reasons vary, but a study in the journal "Pediatrics" claims a lot of children get sick every year by taking medication their doctors have given them to help them feel better.

Problems ranged from accidental overdoses to adverse reactions, including allergies and side effects. Doctors say younger children were especially vulnerable, making up roughly 43 percent of the half-million children yearly who show up at clinics and emergency rooms with bad reactions to medications.

Dr. Barbara Crouch, director of the Utah Poison Control Center, says they get a lot of calls related to bad reactions to medications. She says parents need to watch their children closely, especially if it's the first time they've taken the medicine.

She said, "So skin reactions that might be a clue to a potential allergic reactions, certainly difficulty breathing or an untoward sedation."

Crouch says parents should speak with their doctors and pharmacists about what some of the more serious potential side effects are so they can better monitor their children's reactions.

In July, the Poison Control Center put out a paper on what it calls "Tenfold" dosing errors in young children. That study concluded children are particularly vulnerable to dosing errors because the dose is often based on a child's weight. The paper says one scenario involves health care providers simply misplacing a decimal.

E-mail: mgiauque@ksl.com

Increased mortality and cardiovascular morbidity associated with NSAIDs

 

September 24, 2009
BACKGROUND: Accumulating evidence indicates increased cardiovascular risk associated with nonsteroidal anti-inflammatory drug (NSAID) use, in particular in patients with established cardiovascular disease.

We studied the risk of death and hospitalization because of acute myocardial infarction and heart failure (HF) associated with use of NSAIDs in an unselected cohort of patients with HF.

METHODS: We identified 107,092 patients surviving their first hospitalization because of HF between January 1, 1995, and December 31, 2004, and their subsequent use of NSAIDs from individual-level linkage of nationwide registries of hospitalization and drug dispensing by pharmacies in Denmark. Data analysis was performed using Cox proportional hazard models adjusted for age, sex, calendar year, comorbidity, medical treatment, and severity of disease, and propensity-based risk-stratified models and case-crossover models.

 

http://researchinghealth.com/content/view/968/35/

 

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