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Flagyl
Manufacturer: Pfizer
Metronidazole is a nitroimidazole antibiotic drug used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. It is marketed by Pfizer under the trade name Flagyl, and also by various generic manufacturers.
Metronidazole is also used in the treatment of the dermatological condition rosacea, where it is marketed by Galderma under the trade names Rozex and MetroGel.
Contact Dermatitis. 2006 Sep;55(3):192-3.
.Piskin G, Mekkes JR.
Department of Dermatology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands. g.piskin@amc.uva.nl
PMID: 16918620 [PubMed - in process]
Am J Public Health. 2003 Mar;93(3):489-92.
Chen KT, Twu SJ, Chang HJ, Lin RS.
Field Epidemiology Training Program, Center for Disease Control, Department of Health, Taipei, Taiwan, Republic of China.
OBJECTIVES: This study sought to identify the risk factors associated with an outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among Filipino laborers in Taiwan. METHODS: Forty-six SJS/TEN patients were matched to 92 controls according to month of arrival in Taiwan, sex, and age.
RESULTS: The odds ratio for development of SJS/TEN was 9.5 (95% confidence interval [CI] = 3.9, 23.9) among workers who had used both metronidazole and mebendazole sometime in the preceding 6 weeks.
In addition, a gradient increase in the occurrence of SJS/TEN was found with an increasing level of exposure to metronidazole. CONCLUSIONS: This outbreak highlights the risk of SJS/TEN resulting from the use of both metronidazole and mebendazole and the need for control measures.
PMID: 12604501 [PubMed - indexed for MEDLINE]