Individuals with Stevens-Johnson syndrome or toxic epidermal necrolysis are hospitalized. Any drugs suspected of causing the disorder are immediately discontinued. When possible, people are treated in a burn unit and given scrupulous care to avoid infection.

If the person survives, the skin grows back on its own, and unlike burns, skin grafts are not needed.

Fluids and salts, which are lost through the damaged skin, are replaced intravenously.

Use of corticosteroids to treat the disorder is controversial. Some doctors believe that giving large doses within the first few days is beneficial, whereas others believe that corticosteroids should not be used.

These drugs suppress the immune system, which increases the potential for serious infection. If infection develops, doctors give antibiotics immediately.

In many cases, doctors give intravenous human immunoglobulin (IVIg) to treat toxic epidermal necrolysis. This substance helps to prevent further immune damage to the skin and further progression of blistering.